Vitamin C is used in combination with your Microdosing cycle to enhance the therapeutic effects of psilocybin. We explain the benefits:
1. Bioavailability
Vitamin C Increases the bioavailability of psilocybin, by increasing the activity of the liver enzyme CYP450, which is involved in the metabolism of psilocybin (1) (2). This increases the amount of level of psilocybin that reaches the brain which leads to longer lasting and stronger experience
2. Cell Protection
Vitamin C acts as an antioxidant that can help protect cells from damage caused by harmful molecules called free radicals. Vitamin C helps to improve the healing and regeneration of cells. (3) Also Vitamin C supports the Immune system by enhancing the activity of white blood cells to fight off infections and protect against stressors which contribute to cell protection.
3. Reduce inflammation
There have been several studies that suggest supplementing with vitamin C improved symptoms of depression in individuals who were deficient in the nutrient (4). Vitamin C may help regulate levels of neurotransmitters such as serotonin and dopamine, which play a role in mood regulation. Also it has anti-inflammatory effects which may also be beneficial for individuals with depression, as chronic low-grade inflammation has been linked to the development of mood disorders. (5)
4. Reduce side effects
Vitamin C may help to protect the brain from some of the negative effects of psilocybin such as nausea, anxiety or paranoia by reducing oxidative stress in the brain. Reducing oxidative stress in the brain may have several benefits including improving brain function, reducing risk of neurodegenerative diseases and supporting overall brain health. (6)
1. "Metabolic fate of psilocybin in the rat," Journal of Pharmacy and Pharmacology, 1991
2. "In vitro evaluation of the effect of ascorbic acid on cytochrome P450 enzymes," Psychopharmacology, 2002
3. "Vitamin C: antioxidant and immunomodulator," Nutrition Reviews, 2002.
4. "The effect of vitamin C supplementation on symptoms of depression in patients with major depressive disorder: a randomized controlled trial," Journal of Affective Disorders, 2016.
5. Vitamin C supplementation reduces inflammation and oxidative stress in patients with major depressive disorder," Nutritional Neuroscience, 2018.
6. "Vitamin C modulates oxidative stress, neuroinflammation and neurodegeneration," Banerjee P et al., Journal of Neurochemistry, 2015.
4 helende voordelen van vitamine C en microdosering
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